Basal cell carcinoma bcc, first described by jacob in 1827, 1 is the most common malignant neoplasm of humans. Basal cell carcinoma bcc is the most common skin tumor and contains several different histopathological types. Jul 07, 2016 basal cell and adenoid cystic carcinoma rafael e. Their recognition is important particularly when the. Adenoid cystic carcinoma acc is primarily recognized as malignant neoplasm of the major and minor salivary glands, it may also infrequently arise from a variety of other rare sites specially those having mucous glands, like respiratory tract, external auditory canal, breast, lacrimal gland, uterus, vulva, cervix, prostate, thymus, skin, and esophagus 1,2. Optimal treatment outcome should comprise complete removal of the tumor to the margin of normal tissue with the best possible aesthetic result.
Histopathology of this rare variant of basal cell carcinoma with eccrine differentiation adenoid shows arrangement of cells in the intertwining strands and radially around islands table 1. Distinction of basaloid carcinoma of the prostate from benign basal cell lesions by using immunohistochemistry for bcl2 and ki67. Besides histomorphological clues, immunohistochemistry studies are very helpful in the. Histopathology images of adenoid cystic carcinoma, tongue by. A the superficial parotid layer of the parotid gland was removed, and the mass was excised. Jan 14, 2020 beneath the secretory lining is a layer of basal cells as well as interspersed endocrine.
However, histopathology remains the gold standard for bcc subtyping 58. Adenoid type of bcc is one of the rare histopathological types of bcc which has not found to have any site predilection. A case report of a rare histopathological subtype with dermoscopic aspects. Introduction basal cell carcinoma is the most common cutaneous malignancy, arising from basally located cells of epidermis and pilosebaceous unit. Diagnosis and treatment of basal cell and squamous cell. Cervical adenoid basal tumors comprised of adenoid basal. Adenoid basal cell carcinoma a rare variant and a mimic. A search of the english literature since the first description reveals only 33 cases,59. Primary basal cell carcinoma of the prostate with concurrent. Their recognition is important particularly when the component tumours have different biological behaviours. Adenoid basal carcinoma of the uterine cervix, first distinguished from adenoid cystic carcinoma by baggish and woodruff in 1966, accounts for less than 1% of all cervical adenocarcinomas. Basal cell carcinoma, adenoid type definition of basal. Of 14 potential cases of lowgrade adenoid basal tumor associated with additional types of invasive carcinoma, 10 retrievable cases 9 consultation cases and 1 routine case were identified.
Amin, md key facts terminology malignant neoplasm composed primarily of basaloid cells arising putatively from prostatic basal cells clinical issues wide age range 2889 years, but majority occur in older men most commonly presents with obstructive urinary symptoms normal. Clinical features of reported cases of adenoid type of basal cell carcinoma bcc on histopathology click here to view histopathology of this rare variant shows arrangement of cells in the intertwining strands and radially around islands of connective tissue, resulting in a tumour with a lace like pattern. A clinical, histological, and immunocytochemical comparison with adenoid cystic carcinoma of salivary glands and adenoid basal cell carcinoma. Basal cell carcinoma can broadly be divided into three groups, based on the growth patterns. Jun 07, 2019 basal cell carcinoma bcc is the most common malignant skin tumor which occurs more frequently over the sun exposed parts of body. May 10, 2018 how is basal cell adenocarcinoma of salivary gland treated.
These lesions may be associated, and occasionally show morphologic transitions with, conventional cervical malignancies. The key feature of basal cell carcinoma at low power magnification is of a basaloid epithelial tumour arising from the. Basal cell carcinoma bcc is almost exclusively seen in headneck region with rare involvement of trunk and extremities. A case of cystic basal cell carcinoma which shows a homogenous blueblack area under dermatoscopy. The treatment of basal cell carcinoma depends on the size of the cancer and where it is located. Summary of reported cases of adenoid basal cell carcinoma with varied clinical presentations.
Basal cell carcinoma and squamous cell carcinoma are different forms of nonmelanoma skin cancer. Nodular basal cell carcinoma hematoxylin and eosin, 20. Artefactual separation of cells forming the nests from the underlying stroma key feature. Herein, we report an unusual case of basal cell carcinoma bcc and squamous cell carcinoma scc insitu arising from sks in the same patient. A the superficial parotid layer of the parotid gland. We report a case of adenoid basal carcinoma of the uterine cervix discovered incidentally in a 69yearold woman who had been hysterectomized due to endometrial adenocarcinoma of the uterine corpus.
May be associated with minor component of usual type prostatic adenocarcinoma. Basal cell carcinoma bcc is the most common type of skin cancer, thus numerous therapeutic approaches have been developed. While the histology of this lesion is mostly predictable, some of the rare histological variants such as cystic, adenoid, morpheaform, infundibulocystic, pigmented and miscellaneous variants clearcell, signet ring. Hybrid tumours of the salivary gland are rare neoplasms that have been described only in the parotid and palate. Our dermatology online brief report sstudy of basal cell. Learn more about them here, including their signs and. Histologic mimics of basal cell carcinoma archives of. Icd03 seer sitehistology validation list june 18, 2019 10. Out of all basal cell carcinomas, giant basal cell carcinoma represents less than 1%.
It shares the histologic pattern of adenoid cystic carcinoma, and can be differentiated with the help of characteristic histologic features. Surrounding fibromyxoid stroma, squamous differentiation, merges with basal cell hyperplasia. Jan 17, 2006 basal cell carcinoma bcc, first described by jacob in 1827, 1 is the most common malignant neoplasm of humans. Seborrheic keratosis sk is a common benign tumor in which malignancies like melanoma and nonmelanoma skin cancers nmscs can arise rarely. The differential diagnosis of pcaccs in pathology practice can be difficult and a group of primary and metastatic lesions, including adenoid basal cell carcinoma of the skin, should be considered in the differential diagnosis. Multinodular, basaloid cells in clusters, some with punched out lumens. Carcinomas of the sweat glands do not possess a characteristic. Basal cell and adenoid cystic carcinoma basicmedical key. The epithelial proliferations that are designated adenoid basal carcinoma abc in the current classification from the world health organization represent report. Squamous cell carcinoma insitu and basal cell carcinoma. Adenoid cystic carcinoma, tongue adenoid cystic carcinoma, tongue. Basal cell carcinoma bcc is a slow progressing nonmelanocytic skin cancer that arises from basal cells ie, small, round cells found in the lower layer of the epidermis. Adenoid cystic carcinoma is most common in the fifth and sixth decades of life.
Basal cell carcinoma, adenoid type definition of basal cell. Synchronous adenoid cystic variant of basal cell carcinoma in the right lumbar region. The prognosis and outcomes differ greatly and a correct histological diagnosis is vital in the management of these cases. We studied 29 cases of basal cell carcinoma of the prostate including what others call adenoid cystic carcinoma of the prostate. It is a locally destructive tumour with varied clinical and histological appearances.
Only 10% of all basal cell carcinomas are located on the trunk and majority is located on the head and neck. The indolent clinical course and an excellent prognosis unique to. Every year, close to 10 million people get diagnosed with bcc worldwide. While the histology of this lesion is mostly predictable, some of the rare histological variants such as cystic, adenoid, morpheaform, infundibulocystic, pigmented and miscellaneous variants clear cell, signet ring. Basal cell carcinoma bcc is the most common skin cancer in humans, which typically appears over the sunexposed skin as a slow growing, locally invasive lesion that rarely metastasizes. The determination of the precise frequency with which these socalled abcs show. It is characterized by nests of basaloid cells that extend from the epidermis, with neoplastic cells that resemble primordial germ cells. While the histology of this lesion is mostly predictable, some of the rare histological variants such as cystic, adenoid, morpheaform. Further variant morphologies that may be seen in bcc include clear cell change, signet ring cells, granular cells, adamantinomatoids, adenoid. Tumors with a similar histopathological picture are cutaneous adenoid cystic carcinoma and primary cutaneous cribriform apocrine carcinoma. Adenoid variant of basal cell carcinoma medwin publishers.
Adenoid basal carcinoma abc is a rare cervical malignancy accounting for less than 1% of all cervical cancers. It occurs mainly in adults, in the head and neck area, primarily on the face. Histopathological examination of the excised nodule revealed a tumour composed of basaloid cells with an adenoid pattern of growth. The treatment may also depend upon the stage, overall health, age, and patternconfiguration of the tumor. The tumour is commonly seen on nose, eyelids, at the inner canthus of eyes and behind the ears. Adenoid basal carcinoma of the uterine cervix is rare and its cell origin is still obscure. Adenoid basal cell carcinoma a rare variant and a mimic of. Jan 31, 2019 a 67yearoldwoman with a history of basal cell carcinoma bcc and actinic keratosis presented with an asymptomatic lesion on her central forehead for the preceding 3 months. Adenoid variant, basal cell carcinoma, cutaneous adenoid cystic carcinoma.
Dermatopathologists might see a couple in their career. Use of cytology in the diagnosis of basal cell carcinoma. Two different cell populations is an important clue for. Sex distribution of basal cell carcinoma sex number of cases percentage males 12 57. Primary cutaneous adenoid cystic carcinoma pcacc is a very rare malignancy. Adenoid cystic carcinoma is the most common malignant tumor of minor salivary glands occurring in the oral cavity and tongue. Many skin cancers can be removed quickly and easily using a simple surgical procedure, and often no additional treatment is needed. Beneath the secretory lining is a layer of basal cells as well as interspersed endocrine. Pdf adenoid basal cell carcinoma and its mimics researchgate. Basal cell adenoma misdiagnosed as an adenoid cystic carcinoma in the parotid gland 315 no evidence of infiltrating margin.
Basal cell carcinoma bcc is the most common form of nonmelanoma skin cancer occurring in the skin. Site wise distribution of basal cell carcinoma site number of cases percentage head and neck eye lid 6 28. Adenoid basal carcinoma is thought to be derived from the multipotential basal or reserve. Yoneta a, horimoto k, nakahashi k, mori s, maeda k, yamashita t. Adenoid basal cell carcinoma is a rare type of bcc. Superficial bcc is another common variant of bcc 1. A case of cystic basal cell carcinoma which shows a. Generally, all racial and ethnic groups are at risk and the cancer is observed worldwide. It is exclusively seen on sun exposed and hair bearing skin especially of the face. The expression of 3 basal reserve cell in adenoid basal carcinoma.
The most common methods of diagnosis was transurethral resection turp n29 and needle biopsy n9. To our knowledge, this is the first report of such malignant. A combination of surgery, chemotherapy, and radiation therapy are used to treat basal cell adenocarcinoma of salivary gland. Its adenoid variant is a rare histological subtype. Superficial basal cell carcinoma, formerly referred to insitu basal cell carcinoma, is characterized by a superficial proliferation of neoplastic basal cells. What are the risk factors for adenoid basal carcinoma of uterine cervix. Basal cell carcinoma bcc is the most common skin cancer in the white population 1. This tumor is generally responsive to topic chemotherapy, such as imiquimod, or fluorouracil. In the 100 cases with adenoid cystic carcinoma, there were 71 female and 29 male patients. Here, we report a case of cystic basal cell carcinoma, which is relatively rare and might be clinically misdiagnosed. A dermatoscopic examination of the case revealed a homogenous blueblack area usually not seen in bcc. Histopathology images of adenoid cystic carcinoma, tongue. This tumor closely resembles adenoid cystic carcinoma acc, and in fact has been reported as the same entity in some early reports, till the first description by baggish and woodruff in 1966. Ultraviolet b exposure is a significant factor in the development of basal cell and squamous cell carci noma.
A morphologic variant of basal cell carcinoma whcih consists of strands of basaloid cells in a reticulate pattern, which often has prominent stromal mucin and may coexist with solidtype basal cell carcinoma. We report a case of multiple adenoid basal cell carcinomas at unusual sites in a middleaged male patient. Basal cell carcinoma bcc is the most common malignant neoplasm, with an estimated overall lifetime risk of 30% in the united states. Immunohistochemistry is a helpful adjunct, although not imperative, if histological differences are conclusive. Cervical adenoid basal carcinoma associated with invasive. Histologic mimics of basal cell carcinoma archives of pathology. Basal cell adenoma misdiagnosed as an adenoid cystic. Basal cell carcinoma bcc is the most common human malignant neoplasm and is. Adenoid squamous cell carcinoma definition of adenoid. Basal cell carcinoma bcc constitutes 65% of epithelial tumours. Basal cell carcinoma, abbreviated bcc, is an extremely common form of skin cancer. Clinical features of reported cases of adenoid type of basal cell carcinoma bcc on histopathology open in a separate window histopathology of this rare variant shows arrangement of cells in the intertwining strands and radially around islands of connective tissue, resulting in a tumour with a lace like pattern.
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